Article
Multiparameter prediction of myeloid neoplasia risk.
Nature genetics - 1 Sept 2023
Gu Muxin, Kovilakam Sruthi Cheloor, Dunn William G, Marando Ludovica, Barcena Clea, Mohorianu Irina, Smith Alexandra, Kar Siddhartha P, Fabre Margarete A, Gerstung Moritz, Cargo Catherine A, Malcovati Luca, Quiros Pedro M, Vassiliou George S
Abstract excerpt
The myeloid neoplasms encompass acute myeloid leukemia, myelodysplastic syndromes and myeloproliferative neoplasms. Most cases arise from the shared ancestor of clonal hematopoiesis (CH). Here we analyze data from 454,340 UK Biobank participants, of whom 1,808 developed a myeloid neoplasm 0-15 years after recruitment. We describe the differences in CH mutational landscapes and hematology/biochemistry test...
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