The structure of the hematopoietic system can explain chronic myeloid leukemia progression.

Abstract excerpt

Almost all cancer types share the hallmarks of cancer and a similar tumor formation: fueled by stochastic mutations in somatic cells. In case of chronic myeloid leukemia (CML), this evolutionary process can be tracked from an asymptomatic long-lasting chronic phase to a final rapidly evolving blast phase. Somatic evolution in CML occurs in the context of healthy blood production, a hierarchical process of cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blast Crisis
• Share to Fusion Proteins, bcr-abl
• Share to Hematopoietic System