Article

Statistical inference of the cellular origin of chronic myeloid leukemia using a discrete-parameter ABC–PMC framework

2025-10-17

Abstract excerpt

Chronic myeloid leukemia (CML) arises from the BCR::ABL1 fusion gene, but the exact stage of cellular differentiation at which the first leukemic cell emerges remains uncertain. We develop a stochastic 27-compartment model of hematopoiesis (blood cell development) using a continuous-time multitype branching process to capture the dynamics of both healthy and cancer cells. To infer the origin of CML, we develop a...

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Literature Corpus work: e948b780-835c-56e6-8f9d-ab95234d5b3f
DOI: 10.1101/2025.10.17.683025

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