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ABCB1 variants and sex affect serotonin transporter occupancy in the brain

7 Sept 2022

Abstract excerpt

Abstract Strategies to personalize psychopharmacological treatment promise to improve efficacy and tolerability. We measured serotonin transporter occupancy immediately after infusion of the widely prescribed P-glycoprotein substrate citalopram and assessed to what extent variants of the ABCB1 gene affect drug target engagement in the brain in vivo. A total of 79 participants (39 female) including 31 patients...

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PMID: 36071112
DOI: 10.1038/s41380-022-01733-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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