Article
ABCB1 Gene Variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta-Analysis Including Results from the CAN-BIND-1 Study.
Clinical pharmacology and therapeutics - 1 Jul 2023
Magarbeh Leen, Hassel Claudia, Choi Maximilian, Islam Farhana, Marshe Victoria S, Zai Clement C, Zuberi Rayyan, Gammal Roseann S, Men Xiaoyu, Scherf-Clavel Maike, Enko Dietmar, Frey Benicio N, Milev Roumen, Soares Claudio N, Parikh Sagar V, Placenza Franca, Strother Stephen C, Hassel Stefanie, Taylor Valerie H, Leri Francesco, Blier Pierre, Farzan Faranak, Lam Raymond W, Turecki Gustavo, Foster Jane A, Rotzinger Susan, Kloiber Stefan, Kennedy James L, Kennedy Sidney H, Bousman Chad A, Müller Daniel J
Abstract excerpt
The P-glycoprotein efflux pump, encoded by the ABCB1 gene, has been shown to alter concentrations of various antidepressants in the brain. In this study, we conducted a systematic review and meta-analysis to investigate the association between six ABCB1 single-nucleotide polymorphisms (SNPs; rs1045642, rs2032582, rs1128503, rs2032583, , and ) and antidepressant treatment outcomes in individuals...