Article
Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression.
Biological psychiatry - 1 Aug 2009
Sullivan Gregory M, Ogden R Todd, Oquendo Maria A, Kumar J S Dileep, Simpson Norman, Huang Yung-yu, Mann J John, Parsey Ramin V
Abstract excerpt
BACKGROUND: Little is known about the serotonin-1A receptor (5-HT1A) in bipolar depression despite altered 5-HT1A binding in major depressive disorder. Utilizing positron emission tomography (PET) and the radioligand N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide ([Carbonyl-C-11]WAY-100635), 5-HT1A binding was compared between depressed bipolar disorder (BD) and controls....
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