Article
Interactions between genetic admixture, ethnic identity, APOE genotype and dementia prevalence in an admixed Cuban sample; a cross-sectional population survey and nested case-control study.
BMC medical genetics - 24 Mar 2011
Teruel Beatriz Marcheco, Rodríguez Juan J Llibre, McKeigue Paul, Mesa T Teresa Collazo, Fuentes Evelyn, Cepero A Adolfo Valhuerdi, Hernandez Milagros A Guerra, Copeland J R M John R M, Ferri Cleusa P, Prince Martin J
Abstract excerpt
BACKGROUND: The prevalence and incidence of dementia are low in Nigeria, but high among African-Americans. In these populations there is a high frequency of the risk-conferring APOE-e4 allele, but the risk ratio is less than in Europeans. In an admixed population of older Cubans we explored the effects of ethnic identity and genetic admixture on APOE genotype, its association with dementia, and dementia...
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