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Article

The transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicans.

PloS one - 1 Jan 2011

Sasse Christoph, Schillig Rebecca, Dierolf Franziska, Weyler Michael, Schneider Sabrina, Mogavero Selene, Rogers P David, Morschhäuser Joachim

Abstract excerpt

The pathogenic yeast Candida albicans can develop resistance to the widely used antifungal agent fluconazole, which inhibits ergosterol biosynthesis, by the overexpression of genes encoding multidrug efflux pumps or ergosterol biosynthesis enzymes. Zinc cluster transcription factors play a centra...

Read the complete abstract on PubMed

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Share to Candida albicans
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21980509
DOI: 10.1371/journal.pone.0025623
PMCID: PMC3181345

Genes

CDR2
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21980509-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicans.PMID 21980509Read ↗

A Zinc Cluster Transcription Factor Contributes to the Intrinsic Fluconazole Resistance of Candida auris.Semantic proximity Read ↗

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The TAC1 Gene in Candida albicans: Structure, Function, and Role in Azole Resistance: A Mini-Review.Semantic proximity Read ↗

Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains.Semantic proximity Read ↗

The DNA-binding domain of CaNdt80p is required to activate CDR1 involved in drug resistance in Candida albicans.Semantic proximity Read ↗

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Functional Dissection of a Candida albicans Zinc Cluster Transcription Factor, the Multidrug Resistance Regulator Mrr1Semantic proximity Read ↗

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