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Article

Functional Analysis of cis - and trans -Acting Elements of the Candida albicans CDR2 Promoter with a Novel Promoter Reporter System

27 Jun 2009

Abstract excerpt

Azole resistance in Candida albicans can be mediated by the upregulation of the ATP binding cassette transporter genes CDR1 and CDR2. Both genes are regulated by a cis-acting element called the drug-responsive element (DRE), with the consensus sequence 5'-CGGAWATCGGATATTTTTTT-3', and the transcription factor Tac1p. In order to analyze in detail the DRE sequence necessary for the regulation of CDR1 and CDR2 and...

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PMID: 19561319
DOI: 10.1128/ec.00069-09

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Functional Analysis of cis - and trans -Acting Elements of the Candida albicans CDR2 Promoter with a Novel Promoter Reporter SystemPMID 19561319Read ↗

TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.Semantic proximity Read ↗

A common drug‐responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2 , two genes involved in antifungal drug resistanceSemantic proximity Read ↗

Genome-Wide Expression and Location Analyses of the Candida albicans Tac1p RegulonSemantic proximity Read ↗

The TAC1 Gene in Candida albicans: Structure, Function, and Role in Azole Resistance: A Mini-Review.Semantic proximity Read ↗

The H741D mutation in Tac1p contributes to the upregulation of CDR1 and CDR2 expression in Candida albicans.Semantic proximity Read ↗

Nonidentical function of Upc2A binding sites in the Candida glabrata CDR1 promoterSemantic proximity Read ↗

Relative Contributions of the <i>Candida albicans</i> ABC Transporters Cdr1p and Cdr2p to Clinical Azole ResistanceSemantic proximity Read ↗

Transcriptional Activation and Increased mRNA Stability Contribute to Overexpression of CDR1 in Azole-Resistant Candida albicansSemantic proximity Read ↗

CDR1, a multidrug resistance gene from Candida albicans, contains multiple regulatory domains in its promoter and the distal AP-1 element mediates its induction by miconazole.Semantic proximity Read ↗

A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans.Semantic proximity Read ↗

Comparison of Gene Expression Profiles of Candida albicans Azole-Resistant Clinical Isolates and Laboratory Strains Exposed to Drugs Inducing Multidrug TransportersSemantic proximity Read ↗

Mediator Tail Module Is Required for Tac1-Activated CDR1 Expression and Azole Resistance in Candida albicans.Semantic proximity Read ↗

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