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Article

TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.

Eukaryotic cell - 1 Dec 2004

Coste Alix T, Karababa Mahir, Ischer Françoise, Bille Jacques, Sanglard Dominique

Abstract excerpt

The ABC transporter genes CDR1 and CDR2 can be upregulated in Candida albicans developing resistance to azoles or can be upregulated by exposing cells transiently to drugs such as fluphenazine. The cis-acting drug-responsive element (DRE) present in the promoters of both genes and necessary for their upregulation contains 5'-CGG-3' triplets that are often recognized by transcriptional activators with Zn(2)-Cys(6)...

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Topics

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Share to ATP-Binding Cassette Transporters
Share to Azoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to beta-Galactosidase

Share to Blotting, Northern

Share to Candida albicans

Share to Genome, Fungal

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Source

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Identifiers

PMID: 15590837
DOI: 10.1128/EC.3.6.1639-1652.2004
PMCID: PMC539021

Genes

TAC1
CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.PMID 15590837Read ↗

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A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans.Semantic proximity Read ↗

The H741D mutation in Tac1p contributes to the upregulation of CDR1 and CDR2 expression in Candida albicans.Semantic proximity Read ↗

The zinc cluster transcription factor Tac1p regulates <i>PDR16</i> expression in <i>Candida albicans</i>Semantic proximity Read ↗

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