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Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease

11 Aug 2022

Abstract excerpt

The immediate early gene Arc is a master regulator of synaptic function and a critical determinant of memory consolidation. Here, we show that Arc interacts with dynamic chromatin and closely associates with histone markers for active enhancers and transcription in cultured rat hippocampal neurons. Both these histone modifications, H3K27Ac and H3K9Ac, have recently been shown to be upregulated in late-onset...

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PMID: 36009494
DOI: 10.3390/biomedicines10081946

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