Article

Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease

2019-11-07

Abstract excerpt

<h4>ABSTRACT</h4> The immediate-early gene Arc is a master regulator of synaptic function and a critical determinant of memory consolidation. Arc protein is localized to excitatory synapses, where it controls AMPA receptor endocytosis, and to the nucleus, where it associates with Tip60, a subunit of a chromatin modifying complex. Here we show that Arc interacts with dynamic chromatin loops and associates with his...

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Literature Corpus work: 784e0918-f1fa-5d5c-964b-2557e777d2c3
DOI: 10.1101/833988

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