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Article

Gene expression parallels synaptic excitability and plasticity changes in Alzheimer’s disease

25 Aug 2015

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by abnormal accumulation of β-amyloid and tau and synapse dysfunction in memory-related neural circuits. Pathological and functional changes in the medial temporal lobe, a region essential for explicit memory encoding, contribute to cognitive decline in AD. Surprisingly, functional imaging studies show increased activity of the hippocampus and...

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PMID: 26379494
DOI: 10.3389/fncel.2015.00318

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