Article

Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems

2018-02-23

Abstract excerpt

Genomic enhancer elements regulate gene expression programs important for neuronal fate and function and are implicated in brain disease states. Enhancers undergo bidirectional transcription to generate non-coding enhancer RNAs (eRNAs). However, eRNA function remains controversial. Here, we combined ATAC-Seq and RNA-Seq datasets from three distinct neuronal culture systems in two activity states, enabling genome-w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 930e8e4a-d959-59a6-b5e9-a177051514ac
DOI: 10.1101/270967

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systemsDOI 10.1101/270967Read

Large-scale discovery of neural enhancers for cis-regulation therapiesSemantic proximity Read

Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoidsSemantic proximity Read

Population-level variation of enhancer expression identifies novel disease mechanisms in the human brainSemantic proximity Read

EnhancerTracker: Comparing cell-type-specific enhancer activity of DNA sequence triplets via an ensemble of deep convolutional neural networksSemantic proximity Read

Editing the Neuronal Genome: a CRISPR View of Chromatin Regulation in Neuronal Development, Function, and Plasticity.Semantic proximity Read

Genome-wide identification and characterization of functional neuronal activity-dependent enhancers.Semantic proximity Read

A Chromatin Accessibility Atlas of the Developing Human TelencephalonSemantic proximity Read

eRNA-IDO: a one-stop platform for identification, interactome discovery and functional annotation of enhancer RNAsSemantic proximity Read

Enhancer biology and enhanceropathies.Semantic proximity Read

SEEK to Identify Super Enhancer-Expression Correlated Pairs using Single-cell Multi-omic DataSemantic proximity Read

Single Cell Multiomics Across Nine Mammals Reveals Cell Type Specific Regulatory Conservation in the BrainSemantic proximity Read

Identification of enhancer chromatin signatures involved in dopaminergic induction through multi-omics analysisSemantic proximity Read