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The Arc Gene Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese.

Molecular neurobiology - 1 Feb 2018

Bi Rui, Kong Li-Li, Xu Min, Li Guo-Dong, Zhang Deng-Feng, Li Tao, Fang Yiru, Zhang Chen, Zhang Buchang, Yao Yong-Gang

Abstract excerpt

Alzheimer's disease (AD) is the most common form of dementia. The deposition of β-amyloid (Aβ) plaques in the brain was considered one of the main neuropathological hallmarks of AD. As the loss of synapses always occurs during AD progression, AD has been gradually regarded as a "synaptopathy." The activity-regulated cytoskeleton-associated protein (Arc) was recently identified as a key factor for AD due to its...

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PMID: 28108859
DOI: 10.1007/s12035-017-0397-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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