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Article

A novel ARC gene polymorphism is associated with reduced risk of Alzheimer's disease.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2012

Landgren Sara, von Otter Malin, Palmér Mona Seibt, Zetterström Caroline, Nilsson Staffan, Skoog Ingmar, Gustafson Deborah R, Minthon Lennart, Wallin Anders, Andreasen Niels, Bogdanovic Nenad, Marcusson Jan, Blennow Kaj, Zetterberg Henrik, Kettunen Petronella

Abstract excerpt

Alzheimer's disease (AD) is the most common neurodegenerative disease, and is clinically characterized by cognitive disturbances and the accumulation of the amyloid β (Aβ) peptides in plaques in the brain. Recent studies have shown the links between AD and the immediate-early gene Arc (activity-regulated cytoskeleton-associated protein), involved in synaptic plasticity and memory consolidation. For example, AD...

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PMID: 22622366
DOI: 10.1007/s00702-012-0823-x

Genes

ARC

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