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Article

Ketogenic Diet Modulates Gut Microbiota-Brain Metabolite Axis in a Sex- and Genotype-Specific Manner in APOE4 Mice.

Journal of neurochemistry - 1 Sept 2025

Ivanich Kira, Yackzan Andrew, Flemister Abeoseh, Chang Ya-Hsuan, Xing Xin, Chen Anna, Yanckello Lucille M, Sun McKenna, Aware Chetan, Govindarajan Maalavika, Kramer Skyler, Ericsson Aaron, Lin Ai-Ling

Abstract excerpt

The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), associated with early brain metabolic dysfunction and gut microbiome alterations. Targeting these early changes through dietary interventions may reduce AD risk in asymptomatic carriers. This study evaluated whether a ketogenic diet (KD) could reshape the gut microbiome and enhance key brain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40890565
DOI: 10.1111/jnc.70216
PMCID: PMC12870807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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