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Article

APOE genotype and biological age impact inter-omic associations related to bioenergetics.

Aging - 3 May 2025

Ellis Dylan, Watanabe Kengo, Wilmanski Tomasz, Lustgarten Michael S, Korat Andres V Ardisson, Glusman Gwênlyn, Hadlock Jennifer, Fiehn Oliver, Sebastiani Paola, Price Nathan D, Hood Leroy, Magis Andrew T, Evans Simon J, Pflieger Lance, Lovejoy Jennifer C, Gibbons Sean M, Funk Cory C, Baloni Priyanka, Rappaport Noa

Abstract excerpt

Apolipoprotein E (APOE) modifies human aging; specifically, the ε2 and ε4 alleles are among the strongest genetic predictors of longevity and Alzheimer's disease (AD) risk, respectively. However, detailed mechanisms for their influence on aging remain unclear. In the present study, we analyzed multi-omic association patterns across APOE genotypes, sex, and biological age (BA) axes in 2,229 community dwelling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40323280
DOI: 10.18632/aging.206243
PMCID: PMC12151507

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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