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Article

<i>APOE</i> Genotype and Biological Age Impact Inter-Omic Associations Related to Bioenergetics

2024-10-17

Abstract excerpt

Apolipoprotein E ( APOE ) modifies human aging; specifically, the ε2 and ε4 alleles are among the strongest genetic predictors of longevity and Alzheimer’s disease (AD) risk, respectively. However, detailed mechanisms for their influence on aging remain unclear. Herein, we analyzed inter-omic, context-dependent association patterns across APOE genotypes, sex, and health axes in 2,229 community-dwelling individua...

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Literature Corpus work
2e8811c7-fe34-5ba9-8ebc-36d900e5fb14
DOI
10.1101/2024.10.17.618322
Open publication

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<i>APOE</i> Genotype and Biological Age Impact Inter-Omic Associations Related to BioenergeticsDOI 10.1101/2024.10.17.618322
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