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Article

Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer.

Proceedings of the National Academy of Sciences of the United States of America - 30 Aug 2022

Ryu Jae-Ryeon, Ahuja Suchit, Arnold Corey R, Potts Kyle G, Mishra Aniket, Yang Qiong, Sargurupremraj Muralidharan, Mahoney Douglas J, Seshadri Sudha, Debette Stéphanie, Childs Sarah J

Abstract excerpt

SNPs associated with human stroke risk have been identified in the intergenic region between Forkhead family transcription factors FOXF2 and FOXQ1, but we lack a mechanism for the association. FoxF2 is expressed in vascular mural pericytes and is important for maintaining pericyte number and stabilizing small vessels in zebrafish. The stroke-associated SNPs are located in a previously unknown transcriptional...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35994645
DOI: 10.1073/pnas.2121333119
PMCID: PMC9436329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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