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Article

Association between MEF2A variants and ischemic stroke risk: a case-control study and two prospective cohort studies in a Chinese population.

BMC cardiovascular disorders - 30 Jan 2026

Fang Zhengmei, Chen Yan, Han Xu, Zhu Lijun, Du Mengxue, Jin Yuelong, Shen Chong, Yao Yingshui

Abstract excerpt

BACKGROUND: Transcriptional regulators encoded by the myocyte enhancer factor 2 (MEF2) gene family play a crucial role in cardiac development, homeostasis, and pathology. The relationship between MEF2A and ischemic stroke (IS) remains unclear. METHODS: We performed MEF2A polymorphism genotyping in a case-control study (2497 patients with IS vs. 3135 controls) and a cohort study involving 4080 non-stroke...

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PMID: 41618147
DOI: 10.1186/s12872-026-05537-x
PMCID: PMC12918627

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