Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.

doi:10.1001/jamaneurol.2015.0582

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Article

Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.

JAMA neurology - 1 Jul 2015

Auer Paul L, Nalls Mike, Meschia James F, Worrall Bradford B, Longstreth W T, Seshadri Sudha, Kooperberg Charles, Burger Kathleen M, Carlson Christopher S, Carty Cara L, Chen Wei-Min, Cupples L Adrienne, DeStefano Anita L, Fornage Myriam, Hardy John, Hsu Li, Jackson Rebecca D, Jarvik Gail P, Kim Daniel S, Lakshminarayan Kamakshi, Lange Leslie A, Manichaikul Ani, Quinlan Aaron R, Singleton Andrew B, Thornton Timothy A, Nickerson Deborah A, Peters Ulrike, Rich Stephen S

Abstract excerpt

IMPORTANCE: Stroke is the second leading cause of death and the third leading cause of years of life lost. Genetic factors contribute to stroke prevalence, and candidate gene and genome-wide association studies (GWAS) have identified variants associated with ischemic stroke risk. These variants often have small effects without obvious biological significance. Exome sequencing may discover predicted...

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PMID: 25961151
DOI: 10.1001/jamaneurol.2015.0582
PMCID: PMC4673986

Genes

ABCA1
ACOT4
ZFHX3

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