Article
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
Nature genetics - 5 Feb 2012
Bellenguez Céline, Bevan Steve, Gschwendtner Andreas, Spencer Chris C A, Burgess Annette I, Pirinen Matti, Jackson Caroline A, Traylor Matthew, Strange Amy, Su Zhan, Band Gavin, Syme Paul D, Malik Rainer, Pera Joanna, Norrving Bo, Lemmens Robin, Freeman Colin, Schanz Renata, James Tom, Poole Deborah, Murphy Lee, Segal Helen, Cortellini Lynelle, Cheng Yu-Ching, Woo Daniel, Nalls Michael A, Müller-Myhsok Bertram, Meisinger Christa, Seedorf Udo, Ross-Adams Helen, Boonen Steven, Wloch-Kopec Dorota, Valant Valerie, Slark Julia, Furie Karen, Delavaran Hossein, Langford Cordelia, Deloukas Panos, Edkins Sarah, Hunt Sarah, Gray Emma, Dronov Serge, Peltonen Leena, Gretarsdottir Solveig, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Stefansson Kari, Boncoraglio Giorgio B, Parati Eugenio A, Attia John, Holliday Elizabeth, Levi Chris, Franzosi Maria-Grazia, Goel Anuj, Helgadottir Anna, Blackwell Jenefer M, Bramon Elvira, Brown Matthew A, Casas Juan P, Corvin Aiden, Duncanson Audrey, Jankowski Janusz, Mathew Christopher G, Palmer Colin N A, Plomin Robert, Rautanen Anna, Sawcer Stephen J, Trembath Richard C, Viswanathan Ananth C, Wood Nicholas W, Worrall Bradford B, Kittner Steven J, Mitchell Braxton D, Kissela Brett, Meschia James F, Thijs Vincent, Lindgren Arne, Macleod Mary Joan, Slowik Agnieszka, Walters Matthew, Rosand Jonathan, Sharma Pankaj, Farrall Martin, Sudlow Cathie L M, Rothwell Peter M, Dichgans Martin, Donnelly Peter, Markus Hugh S
Abstract excerpt
Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for...
Read the complete abstract on PubMed