Article
Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration.
Neurology - 29 Mar 2016
Malik Rainer, Traylor Matthew, Pulit Sara L, Bevan Steve, Hopewell Jemma C, Holliday Elizabeth G, Zhao Wei, Abrantes Patricia, Amouyel Philippe, Attia John R, Battey Thomas W K, Berger Klaus, Boncoraglio Giorgio B, Chauhan Ganesh, Cheng Yu-Ching, Chen Wei-Min, Clarke Robert, Cotlarciuc Ioana, Debette Stephanie, Falcone Guido J, Ferro Jose M, Gamble Dale M, Ilinca Andreea, Kittner Steven J, Kourkoulis Christina E, Lemmens Robin, Levi Christopher R, Lichtner Peter, Lindgren Arne, Liu Jingmin, Meschia James F, Mitchell Braxton D, Oliveira Sofia A, Pera Joana, Reiner Alex P, Rothwell Peter M, Sharma Pankaj, Slowik Agnieszka, Sudlow Cathie L M, Tatlisumak Turgut, Thijs Vincent, Vicente Astrid M, Woo Daniel, Seshadri Sudha, Saleheen Danish, Rosand Jonathan, Markus Hugh S, Worrall Bradford B, Dichgans Martin
Abstract excerpt
OBJECTIVE: To investigate the influence of common and low-frequency genetic variants on the risk of ischemic stroke (all IS) and etiologic stroke subtypes. METHODS: We meta-analyzed 12 individual genome-wide association studies comprising 10,307 cases and 19,326 controls imputed to the 1000 Genomes (1 KG) phase I reference panel. We selected variants showing the highest degree of association (p < 1E-5) in the...
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