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Article

Chromatin architecture around stroke haplotypes provides evidence that genetic risk is conferred through vascular cells.

Epigenomics - 1 Mar 2022

Tutino Vincent M, Kuo Cathleen C, Avasthi Naval, Rai Hamid H, Waqas Muhammad, Siddiqui Adnan H, Jarvis James N, Poppenberg Kerry E

Abstract excerpt

Introduction: Genome-wide association studies (GWAS) have identified numerous stroke-associated SNPs. To understand how SNPs affect gene expression related to increased stroke risk, we studied epigenetic landscapes surrounding 26 common, validated stroke-associated loci. Methods: We mapped the SNPs to linkage disequilibrium (LD) blocks and examined H3K27ac, H3K4me1, H3K9ac, and H3K4me3 histone marks and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35184600
DOI: 10.2217/epi-2021-0307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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