Article
Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.
Genome medicine - 5 Feb 2024
Akinyemi Rufus O, Tiwari Hemant K, Srinivasasainagendra Vinodh, Akpa Onoja, Sarfo Fred S, Akpalu Albert, Wahab Kolawole, Obiako Reginald, Komolafe Morenikeji, Owolabi Lukman, Osaigbovo Godwin O, Mamaeva Olga A, Halloran Brian A, Akinyemi Joshua, Lackland Daniel, Obiabo Olugbo Y, Sunmonu Taofik, Chukwuonye Innocent I, Arulogun Oyedunni, Jenkins Carolyn, Adeoye Abiodun, Agunloye Atinuke, Ogah Okechukwu S, Ogbole Godwin, Fakunle Adekunle, Uvere Ezinne, Coker Motunrayo M, Okekunle Akinkunmi, Asowata Osahon, Diala Samuel, Ogunronbi Mayowa, Adeleye Osi, Laryea Ruth, Tagge Raelle, Adeniyi Sunday, Adusei Nathaniel, Oguike Wisdom, Olowoyo Paul, Adebajo Olayinka, Olalere Abimbola, Oladele Olayinka, Yaria Joseph, Fawale Bimbo, Ibinaye Philip, Oyinloye Olalekan, Mensah Yaw, Oladimeji Omotola, Akpalu Josephine, Calys-Tagoe Benedict, Dambatta Hamisu A, Ogunniyi Adesola, Kalaria Rajesh, Arnett Donna, Rotimi Charles, Ovbiagele Bruce, Owolabi Mayowa O
Abstract excerpt
BACKGROUND: African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study involving 16 sites in West Africa. We conducted the first-ever genome-wide association study (GWAS) of stroke in indigenous Africans. METHODS: Cases were consecutively...
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