Article
Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcription phenotypes share genetic variation with schizophrenia risk.
Translational psychiatry - 20 Aug 2022
McKinney Brandon C, McClain Lora L, Hensler Christopher M, Wei Yue, Klei Lambertus, Lewis David A, Devlin Bernie, Wang Jiebiao, Ding Ying, Sweet Robert A
Abstract excerpt
DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an important role in the regulation of gene expression. Single-nucleotide polymorphisms (SNPs) associated with schizophrenia (SZ) by genome-wide association studies (GWAS) often influence local DNAm levels. Thus, DNAm alterations, acting through effects on gene expression, represent one potential mechanism by which SZ-associated...
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