Article
Identification of schizophrenia-associated loci by combining DNA methylation and gene expression data from whole blood.
European journal of human genetics : EJHG - 1 Aug 2015
van Eijk Kristel R, de Jong Simone, Strengman Eric, Buizer-Voskamp Jacobine E, Kahn René S, Boks Marco P, Horvath Steve, Ophoff Roel A
Abstract excerpt
Emerging evidence suggests that schizophrenia (SZ) susceptibility involves variation at genetic, epigenetic and transcriptome levels. We describe an integrated approach that leverages DNA methylation and gene expression data to prioritize genetic variation involved in disease. DNA methylation levels were obtained from whole blood of 260 SZ patients and 250 unaffected controls of which a subset with gene...
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