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A monocyte gene expression signature in the early clinical course of Parkinson’s disease

11 Jul 2018

Abstract excerpt

Microglia are the main immune cells of the brain and express a large genetic pattern of genes linked to Parkinson's disease risk alleles. Monocytes like microglia are myeloid-lineage cells, raising the questions of the extent to which they share gene expression with microglia and whether they are already altered early in the clinical course of the disease. To decipher a monocytic gene expression signature in...

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PMID: 30018301
DOI: 10.1038/s41598-018-28986-7

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