Article
Prioritization of cancer driver gene with prize-collecting steiner tree by introducing an edge weighted strategy in the personalized gene interaction network.
BMC bioinformatics - 16 Aug 2022
Zhang Shao-Wu, Wang Zhen-Nan, Li Yan, Guo Wei-Feng
Abstract excerpt
BACKGROUND: Cancer is a heterogeneous disease in which tumor genes cooperate as well as adapt and evolve to the changing conditions for individual patients. It is a meaningful task to discover the personalized cancer driver genes that can provide diagnosis and target drug for individual patients. However, most of existing methods mainly ranks potential personalized cancer driver genes by considering the...
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