Article
Discovering personalized driver mutation profiles of single samples in cancer by network control strategy.
Bioinformatics (Oxford, England) - 1 Jun 2018
Guo Wei-Feng, Zhang Shao-Wu, Liu Li-Li, Liu Fei, Shi Qian-Qian, Zhang Lei, Tang Ying, Zeng Tao, Chen Luonan
Abstract excerpt
Motivation: It is a challenging task to discover personalized driver genes that provide crucial information on disease risk and drug sensitivity for individual patients. However, few methods have been proposed to identify the personalized-sample driver genes from the cancer omics data due to the lack of samples for each individual. To circumvent this problem, here we present a novel single-sample controller...
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