Article
Frequency of quorum-sensing mutations in Pseudomonas aeruginosa strains isolated from different environments.
Microbiology (Reading, England) - 1 Dec 2022
O'Connor Kathleen, Zhao Conan Y, Mei Madeline, Diggle Stephen P
Abstract excerpt
Pseudomonas aeruginosa uses quorum sensing (QS) to coordinate the expression of multiple genes necessary for establishing and maintaining infection. It has previously been shown that lasR QS mutations frequently arise in cystic fibrosis (CF) lung infections, however, there has been far less emphasis on determining whether other QS system mutations arise during infection or in other environments. To test this, we...
Topics
- Humans
- Bacterial Proteins
- Cystic Fibrosis
- Gene Expression Regulation, Bacterial
- Mutation
- Pseudomonas aeruginosa
- Pseudomonas Infections
- Quorum Sensing
- Trans-Activators