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Article

Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jan 2009

Hoffman Lucas R, Kulasekara Hemantha D, Emerson Julia, Houston Laura S, Burns Jane L, Ramsey Bonnie W, Miller Samuel I

Abstract excerpt

BACKGROUND: Pseudomonas aeruginosa with mutations in the transcriptional regulator LasR chronically infect the airways of people with cystic fibrosis (CF), yet the prevalence and clinical implications of lasR mutant infection are unknown. METHODS: In an exploratory study, we screened 166 P. aeruginosa isolates from 58 CF patients for LasR inactivation and mucoidy, and compared clinical characteristics among...

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Identifiers

PMID: 18974024
DOI: 10.1016/j.jcf.2008.09.006
PMCID: PMC2631641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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