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Article

Models of LRRK2-Associated Parkinson's Disease.

Advances in neurobiology - 1 Jan 2017

Xiong Yulan, Dawson Ted M, Dawson Valina L

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic causes of Parkinson's disease (PD) and also one of the strongest genetic risk factors in sporadic PD. The LRRK2 protein contains a GTPase and a kinase domain and several protein-protein interaction domains. Both in vitro and in vivo assays in different model systems have provided tremendous insights into the molecular...

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Identifiers

PMID: 28353284
DOI: 10.1007/978-3-319-49969-7_9
PMCID: PMC5535810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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