Article
The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse.
Neurobiology of disease - 1 Sept 2017
Giesert F, Glasl L, Zimprich A, Ernst L, Piccoli G, Stautner C, Zerle J, Hölter S M, Vogt Weisenhorn D M, Wurst W
Abstract excerpt
The aim of the present study was to further explore the in vivo function of the Leucine-rich repeat kinase 2 (LRRK2)-gene, which is mutated in certain familial forms of Parkinson's disease (PD). We generated a mouse model harboring the disease-associated point mutation R1441C in the GTPase domain...
Topics
- Animals
- Arginine
- Cysteine
- Disease Models, Animal
- Exploratory Behavior
- Gait
- Genotype
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mice
- Mice, Transgenic
- Motor Activity
- Parkinson Disease
- Point Mutation
- Prodromal Symptoms
- Recognition, Psychology