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Article

Network regression analysis in transcriptome-wide association studies.

BMC genomics - 6 Aug 2022

Jin Xiuyuan, Zhang Liye, Ji Jiadong, Ju Tao, Zhao Jinghua, Yuan Zhongshang

Abstract excerpt

BACKGROUND: Transcriptome-wide association studies (TWASs) have shown great promise in interpreting the findings from genome-wide association studies (GWASs) and exploring the disease mechanisms, by integrating GWAS and eQTL mapping studies. Almost all TWAS methods only focus on one gene at a time, with exception of only two published multiple-gene methods nevertheless failing to account for the inter-dependence...

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Identifiers

PMID: 35933330
DOI: 10.1186/s12864-022-08809-w
PMCID: PMC9356418

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