Article

Modeling Regulatory Network Topology Improves Genome-Wide Analyses of Complex Human Traits

2020-03-14

Abstract excerpt

Genome-wide association studies (GWAS) have cataloged many significant associations between genetic variants and complex traits. However, most of these findings have unclear biological significance, because they often have small effects and occur in non-coding regions. Integration of GWAS with gene regulatory networks addresses both issues by aggregating weak genetic signals within regulatory programs. Here we dev...

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Literature Corpus work: c486b3a9-cd3e-5010-9570-69f0369c3fbb
DOI: 10.1101/2020.03.13.990010

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