Article
Accounting for nonlinear effects of gene expression identifies additional associated genes in transcriptome-wide association studies.
Human molecular genetics - 21 Jul 2022
Lin Zhaotong, Xue Haoran, Malakhov Mykhaylo M, Knutson Katherine A, Pan Wei
Abstract excerpt
Transcriptome-wide association studies (TWAS) integrate genome-wide association study (GWAS) data with gene expression (GE) data to identify (putative) causal genes for complex traits. There are two stages in TWAS: in Stage 1, a model is built to impute gene expression from genotypes, and in Stage 2, gene-trait association is tested using imputed gene expression. Despite many successes with TWAS, in the current...
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