PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk.

doi:10.1038/s41598-022-17058-6

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Article

PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk.

Scientific reports - 2 Aug 2022

Lopatko Lindman Karin, Jonsson Caroline, Weidung Bodil, Olsson Jan, Pandey Janardan P, Prokopenko Dmitry, Tanzi Rudolph E, Hallmans Göran, Eriksson Sture, Elgh Fredrik, Lövheim Hugo

Abstract excerpt

PILRA (rs1859788 A > G) has been suggested to be a protective variant for Alzheimer's disease (AD) and is an entry co-receptor for herpes simplex virus-1. We conducted a nested case-control study of 360 1:1-matched AD subjects. Interactions between the PILRA-A allele, APOE risk variants (ε3/ε4 or ε4/ε4) and GM17 for AD risk were modelled. The associations were cross-validated using two independent whole-genome...

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PMID: 35918447
DOI: 10.1038/s41598-022-17058-6
PMCID: PMC9346002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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