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A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex–associated Alzheimer's disease

1 Jan 2019

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Abstract Introduction Herpes simplex virus type 1 (HSV1) in combination with genetic susceptibility has previously been implicated in Alzheimer's disease (AD) pathogenesis. Methods Plasma from 360 AD cases, obtained on average 9.6 years before diagnosis, and their age‐ and sex‐matched controls, were analyzed for anti–HSV1 immunoglobulin (Ig) G with enzyme‐linked immunosorbent assays (ELISAs). A POE genotype and...

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PMID: 31921962
DOI: 10.1016/j.trci.2019.09.014

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