Article

Ramp sequence may explain synonymous variant association with Alzheimer’s disease in the Paired Immunoglobulin-like Type 2 Receptor Alpha ( <i>PILRA</i> )

2025-01-08

Abstract excerpt

<h4>BACKGROUND</h4> Synonymous variant NC_000007.14:g.100373690T>C ( rs2405442:T>C ) in the Paired Immunoglobulin-like Type 2 Receptor Alpha ( PILRA ) gene was previously associated with decreased risk for Alzheimer’s disease (AD) in genome-wide association studies, but its biological impact is largely unknown. <h4>OBJECTIVE</h4> We hypothesized that rs2405442:T>C decreases mRNA and protein levels by destro...

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Literature Corpus work: 56325d9c-613a-5943-b1c5-22ba078ece1e
DOI: 10.1101/2025.01.06.631528

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