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Article

An Ig γ Marker Genotype Is a Strong Risk Factor for Alzheimer Disease, Independent of Apolipoprotein E ε4 Genotype.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2020

Pandey Janardan P, Olsson Jan, Weidung Bodil, Kothera Ronald T, Johansson Anders, Eriksson Sture, Hallmans Göran, Elgh Fredrik, Lövheim Hugo

Abstract excerpt

Increasing evidence implicates HSV type 1 (HSV1) in the pathogenesis of late-onset Alzheimer disease (AD). HSV1 has evolved highly sophisticated strategies to evade host immunosurveillance. One strategy involves encoding a decoy Fcγ receptor (FcγR), which blocks Fc-mediated effector functions, such as Ab-dependent cellular cytotoxicity. Ig γ marker (GM) allotypes, encoded by highly polymorphic IGHG genes on...

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Identifiers

PMID: 32709662
DOI: 10.4049/jimmunol.2000351
PMCID: PMC8973829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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