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Article

Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2016

Ebbert Mark T W, Boehme Kevin L, Wadsworth Mark E, Staley Lyndsay A, Mukherjee Shubhabrata, Crane Paul K, Ridge Perry G, Kauwe John S K

Abstract excerpt

INTRODUCTION: Ebbert et al. reported gene-gene interactions between rs11136000-rs670139 (CLU-MS4A4E) and rs3865444-rs670139 (CD33-MS4A4E). We evaluate these interactions in the largest data set for an epistasis study. METHODS: We tested interactions using 3837 cases and 4145 controls from Alzheimer's Disease Genetics Consortium using meta-analyses and permutation analyses. We repeated meta-analyses stratified by...

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Share to Alzheimer Disease
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Source

Open in PubMed Open full text

Identifiers

PMID: 26449541
DOI: 10.1016/j.jalz.2015.08.163
PMCID: PMC4744542

Genes

CLU
APOE
APP
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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