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Article

Influence of HLA-C environment on the spontaneous clearance of hepatitis C in European HIV-HCV co-infected individuals.

Clinical and experimental immunology - 1 Apr 2021

Legrand N, David G, Rodallec A, Gaultier A, Salmon D, Cesbron A, Wittkop L, Raffi F, Gendzekhadze K, Retière C, Allavena C, Gagne K

Abstract excerpt

Natural killer (NK) cell functions are regulated by diverse inhibitory and activating receptors, including killer cell immunoglobulin-like receptors (KIR), which interact with human leukocyte antigen (HLA) class I molecules. Some KIR/HLA genetic combinations were reported associated with spontaneous clearance (SC) of hepatitis C virus (HCV) but with discordant results, possibly reflecting KIR and/or HLA gene...

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Topics

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Share to Coinfection
Share to HLA-C Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, KIR

Share to Receptors, KIR2DL1

Share to Receptors, KIR2DL2

Share to Receptors, KIR2DL3

Share to Remission, Spontaneous

Share to T-Lymphocyte Subsets

Source

Open in PubMed Open full text

Identifiers

PMID: 33314121
DOI: 10.1111/cei.13562
PMCID: PMC7944354

Genes

KIR2DL2
KIR2DL1
C2
KIR2DS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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