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Article

Characterizing Benzo[a]pyrene-induced lacZ mutation spectrum in transgenic mice using next-generation sequencing.

BMC genomics - 19 Oct 2015

Beal Marc A, Gagné Rémi, Williams Andrew, Marchetti Francesco, Yauk Carole L

Abstract excerpt

BACKGROUND: The transgenic rodent mutation reporter assay provides an efficient approach to identify mutagenic agents in vivo. A major advantage of this assay is that mutant reporter transgenes can be sequenced to provide information on the mode of action of a mutagen and to identify clonally expanded mutations. However, conventional DNA sequence analysis is laborious and expensive for long transgenes, such as...

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Identifiers

PMID: 26481219
DOI: 10.1186/s12864-015-2004-4
PMCID: PMC4617527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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