Article

Multifaceted immune resistance landscapes in human oligodendrocytes protect against cytotoxic T cells and are dysregulated in MS brain cell subsets

2026-04-23

Abstract excerpt

Multiple sclerosis (MS) is a progressive neuroinflammatory demyelinating disease of the central nervous system (CNS) that remains incurable. Autoreactive myelin-specific T cells contribute to immunopathology by directly targeting and damaging oligodendrocytes in situ . In oligodendrocytes, several immune-modulatory functions have been described that can ameliorate immune damage. However, a systematic discovery of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9ebbb944-0886-551b-9401-ed25f3093d70
DOI: 10.64898/2026.04.21.719872

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multifaceted immune resistance landscapes in human oligodendrocytes protect against cytotoxic T cells and are dysregulated in MS brain cell subsetsDOI 10.64898/2026.04.21.719872Read

Comparing Single-Cell Transcriptomes of Blood and Cerebrospinal Fluid Leukocytes in Multiple SclerosisSemantic proximity Read

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosisSemantic proximity Read

Oligodendroglia as functional effectors of Multiple Sclerosis risk variantsSemantic proximity Read

GWAS highlights the neuronal contribution to multiple sclerosis susceptibilitySemantic proximity Read

A Deep Transcriptome Meta-Analysis Reveals Sex-based Molecular Differences in Multiple SclerosisSemantic proximity Read

Uncovering immune characteristics of neurons in the context of multiple sclerosis and experimental autoimmune encephalomyelitisSemantic proximity Read

Immune-responsive gene-1: The mitochondrial Key to Th17 Cell Pathogenicity in CNS AutoimmunitySemantic proximity Read

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis.Semantic proximity Read

Senolytic treatment depletes microglia and decreases severity of experimental autoimmune encephalomyelitisSemantic proximity Read

The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibilitySemantic proximity Read

The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis.Semantic proximity Read