Article

EMMPRIN confers metabolic advantage for monocytes and macrophages to promote disease in a model of multiple sclerosis

2024-08-11

Abstract excerpt

Monocytes and monocyte-derived macrophages have important roles in the initiation and progression of multiple sclerosis (MS). These cells undergo metabolic reprogramming to generate immunophenotypes that promote leukocyte infiltration, axonal degeneration and demyelination, worsening MS pathology. The mechanisms that dictate metabolic programs in monocytes and macrophages in MS remain unclear. We previously report...

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Literature Corpus work: dda17a81-8f81-5c4c-85be-ec8a1d984d22
DOI: 10.1101/2024.08.11.607460

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