Article
Genetic variants regulate NR1H3 expression and contribute to multiple sclerosis risk.
Journal of the neurological sciences - 15 Jul 2018
Zhang Yan, Wang Longcai, Jia Haiyang, Liao Mingzhi, Chen Xiaoyun, Xu Jianyong, Bao Yunjuan, Liu Guiyou
Abstract excerpt
A recent study analyzed 2053 multiple sclerosis (MS) cases and 799 healthy controls to investigate whether five genetic variants (rs11039149, rs12221497, rs2279238, rs7120118 and rs7114704) in NR1H3 are associated with MS risk. However this study reported negative results. It is very important that the appropriate samples and approach should be used in replication studies, which may provide the correct...