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Article

The Pro-Inflammatory Deletion Allele of the NF-κB1 Polymorphism Is Characterized by a Depletion of Subunit p50 in Sepsis.

International journal of molecular sciences - 8 Jul 2022

Marko Britta, Heurich Paulina, Thon Patrick, Zimmer Frieda, Bergmann Lars, Nowak Hartmuth, Rump Katharina, Koos Björn, Adamzik Michael, Unterberg Matthias, Rahmel Tim

Abstract excerpt

The functionally important NF-κB1 promoter polymorphism (-94ins/delATTG) significantly shapes inflammation and impacts the outcome of sepsis. However, exploratory studies elucidating the molecular link of this genotype-dependent pattern are lacking. Accordingly, we analyzed lipopolysaccharide-stimulated peripheral blood mononuclear cells from both healthy volunteers (n = 20) and septic patients (n = 10). All...

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Identifiers

PMID: 35886907
DOI: 10.3390/ijms23147559
PMCID: PMC9318670

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