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Article

Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF -238A polymorphism.

Immunogenetics - 1 Oct 2009

Pappachan John V, Coulson Tim G, Child Nicholas J A, Markham David J, Nour Sarah M, Pulletz Mark C K, Rose-Zerilli Matthew J, de Courcey-Golder Kim, Barton Sheila J, Yang Ian A, Holloway John W

Abstract excerpt

The systemic inflammatory response syndrome (SIRS) is associated with activation of innate immunity. We studied the association between mortality and measures of disease severity in the intensive care unit (ICU) and functional polymorphisms in genes coding for Toll-like receptor 4 (TLR4), macrophage migratory inhibitory factor (MIF), tumour necrosis factor (TNF) and lymphotoxin-alpha (LTA). Two hundred...

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Source

Identifiers

PMID: 19714324
DOI: 10.1007/s00251-009-0395-6

Genes

TNF
LTA
MIF
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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